Isabel was born in Melbourne, Australia. She was always involved in drama during her time at school and went on to study drama at the Victorian College of Arts and Queensland University of Technology. She spent 3 years playing her first television role, Tasha, in Home and Away and won a Logie Award (for new popular talent) for her performance. In 2008, she moved to Los Angeles. Her breakthrough role came in Transformers: Revenge of the Fallen (2009).