Carla Gugino was born in Sarasota, Florida. She is of Italian (father) and English-Irish (mother) ancestry. Gugino moved with her mother to Paradise, California, when Carla was just five years old. A major modelling agency discovered Carla in San Diego and sent her to New York to begin a new career when she was 15. New York was more than she could handle at that young age, so she returned to LA in the summer, modelling and enrolling in an acting class at the suggestion of her aunt, Carol Merrill, known from Let's Make a Deal (1963).